PV-1 Gene Can Boost Calorie Burn

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Recently researchers at the University of Southern Denmark discovered a novel approach to overcoming weight-loss plateaus, which are a common frustration for many people who need to shed significant weight. The results of this groundbreaking discovery was published in the journal of Cell Metabolism to share findings about a liver protein that controls energy sources.

Normally, when the body experiences reduced calorie intake, the liver shifts from burning carbohydrates to oxidizing fat. However, by suppressing a gene called plasmalemma vesicle-associated protein (PLVAP or PV-1) that plays a critical role in the liver's regulation of energy metabolism during fasting,  researchers were able to “trick” the liver into continuing to burn carbohydrates instead of fat.  

The results were encouraging, showing improved insulin sensitivity, lower blood sugar levels, and sustained calorie burning without adverse effects. This exciting news could be the first step toward reshaping weight-loss strategies for improving an obese or overweight individual’s metabolic health. In addition, findings suggest the potential of pairing gene-switching with existing weight loss medications.

NOTE: The University of Southern Denmark’s PLVAP study on metabolism was initially published in the journal Cell Metabolism. The team of research scientists included Daniel Hansen, Jasmin Jensen, Christian Andersen, Peter Jakobsgaard, Jesper Havelund, Line Lauritsen, Samuel Mandacaru, Majken Siersbæk, Oliver Shackleton, Jonathan Brewer, Blagoy Blagoev, Nils Færgeman, and Kim Ravnskjær (all from SDU). Collaborators from Japan, the USA, and Finland. Danish scientists suggest that targeting the PV-1 gene could be key to overcoming common barriers by offering new hope for those with significant weight-loss goals.

How Cells Trigger Metabolic Changes

After suppressing PLVAP in mice, Danish scientists uncovered new insights into the gene’s role for metabolic regulation in the liver. This genetic manipulation allowed the mice to maintain high carbohydrate utilization while redirecting fat to skeletal muscles, bypassing the liver entirely, and showed no adverse effects. The findings suggest that the PV-1 that is expressed in hepatic stellate cells plays a crucial role in managing the body’s energy sources during periods of fasting.

Without the PLVAP protein, the liver fails to recognize the fasting state, erroneously burning sugar instead of fat and allowing fat to fuel muscle tissues. This discovery could have significant implications for weight-loss treatments, particularly in enhancing the efficacy of the latest prescriptive medications used for appetite regulation and chronic weight management, as well as avoiding dreaded weight loss plateaus triggered by the daily reduction in food intake.

The research also highlights the newly identified metabolic function of hepatic stellate cells, suggesting they may play a pivotal role in energy regulation and cell-to-cell signaling, diverging from previously held assumptions about hepatocytes driving this process. These advancements could lead to more innovative treatments for obesity, diabetes and fatty liver disease, offering new hope for overcoming metabolic challenges by creating long-term health solutions.

Kickstart Your Journey for Weight Control

Prescriptive weight loss medications have been reshaping the way MRC approaches weight management for obese and overweight individuals with certain weight-related medical conditions. By addressing the root causes of weight gain, these cutting-edge treatments mimic the body’s natural hormones making it easier to regulate appetite by delaying gastric emptying of food to increase feelings of fullness, and all while helping to stabilize blood sugar levels.

Without the constant struggle of combatting annoying food cravings or resorting to highly restrictive diets, these incretin mimetics can be paired with lifestyle changes, personalized meal plans, routine physical activity, and lots of support to produce sustainable results. Therapeutic peptides are proven to enhance weight loss, improve metabolic efficiency, and support cardiovascular well-being. However, while the benefits are profound, long-term success requires a comprehensive approach as everyone’s body is different.

For anyone struggling with obesity or weight-related health concerns, medications offer renewed hope. That’s why, at Metabolic Research Center, we combine innovative science-backed programs with personalized one-on-one coaching to provide a sustainable path toward achieving your weight loss goals. Visit us at the medical weight clinic Valdosta to see how our experienced team can help you. All it takes is a quick email or phone call to learn more and schedule a free consultation as your first step toward wellness.