PLVAP Genes May Also Boost Metabolism

---

A select group of research scientists at the University of Southern Denmark uncovered new insights into how the liver’s metabolic processes could revolutionize today’s weight-loss strategies. Their research focused on the plasmalemma vesicle-associated protein (PLVAP or PV-1) gene, which plays a critical role in how the body burns energy during fasting.

Normally, when food intake is reduced or someone is fasting, the liver naturally switches from burning carbohydrates for energy to oxidizing fatty acids. However, in this recent study where the PLVAP gene was removed in mice, researchers found that the metabolic shift was interrupted and the mice’s liver continued burning sugar and fat was redirected to muscles without adverse effects.

The implications for human weight loss and ongoing  weight management are significant. By manipulating the PLVAP gene, researchers suggest it may be possible to “trick” the human liver into maintaining carbohydrate burning even during calorie deficits to potentially eliminate frustrating weight-loss plateaus, that are often experienced by obese or overweight individuals who need to lose substantial amounts of weight.

NOTE: The University of Southern Denmark’s PV-1 study on metabolism was initially published in the journal Cell Metabolism. The team of research scientists included Daniel Hansen, Jasmin Jensen, Christian Andersen, Peter Jakobsgaard, Jesper Havelund, Line Lauritsen, Samuel Mandacaru, Majken Siersbæk, Oliver Shackleton, Jonathan Brewer, Blagoy Blagoev, Nils Færgeman, and Kim Ravnskjær (all from SDU). Collaborators from Japan, the USA, and Finland. Danish scientists suggest that targeting the PLVAP gene could be key to overcoming common barriers by offering new hope for those with significant weight-loss goals.

How Cells Trigger Metabolic Changes

The Danish discovery also opens doors to developing new medications or treatment therapies that could work alongside prescription weight loss medications. Combining these advancements could offer a powerful new approach to achieving sustainable weight control by addressing the reduction of daily food intake without the risk of metabolic slowdowns due to the typical shift to “starvation mode.”

receptor agonists work by mimicking the glucagon-like peptide-1 hormone that is produced in the gastrointestinal tract. This signals the brain to reduce sensations of hunger by slowing the digestion process by delaying gastric emptying from the stomach to the small intestines. Not only does this allow for a more natural reduction in daily food intake but it also makes it easier to avoid overeating at meal times. However, users often face metabolic slowdowns.

The study shed new light on this novel mechanism of liver metabolism regulation that is led by hepatic stellate cells (lipocytes), which were previously not associated with lipid metabolism. The stellate cells are primarily known for their activation after liver injury for producing the collagen-rich extracellular matrix in liver fibrosis. Further research into PV-1’s functions could enhance the efficacy of medications by extending weight loss beyond typical weight-loss plateaus.

Kickstart Your Journey for Weight Control

While weight loss without prescription assistance is always achievable, incretin mimetics have made it possible for many to achieve results that previously seemed out of reach when following the more traditional dietary restrictions and increase in physical activity. These revolutionary new medications are redefining the approach to sustainable weight loss by enhancing blood sugar control by reducing food cravings and promoting a true sense of fullness, which can significantly improve one’s metabolic health and overall well-being.

MRC's compounded medications work by slowing gastric emptying to ensure food stays in the stomach longer, effectively reducing calorie intake. But, they also trigger key metabolic processes that encourage the body to switch to fat-burning mode once glycogen stores are depleted. This metabolic flexibility, regulated by hormones like glucagon and insulin, ensures a consistent energy supply even during fasting periods but can lead to plateaus.

Nonetheless, at the Metabolic Research Center, we’re proud to integrate groundbreaking treatments into our proven weight loss programs that have been honed over past three and a half decades. Visit us at the medical weight loss clinic Eugene to see how our experienced team can help you achieve your goals. All it takes is a quick email or phone call to learn more MRC’s science-backed approach to weight management. But, don’t forget to schedule a free consultation today as a first step toward metabolic wellness.